genetic mutation

noun

plural genetic mutations
: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes
Lacking working copies of the p53 gene, cells can begin to divide without check, though several other genetic mutations are thought to be needed to foster a full-blown malignancy.Natalie Angier

Examples of genetic mutation in a Sentence

Recent Examples on the Web
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In the 2000s, advancements in DNA sequencing led to a swell of genetic research that found that about two-thirds of those familial cases are connected to a handful of genetic mutations. Shayla Love, The Atlantic, 23 Mar. 2025 The genetic mutation prevents skin from properly forming, and makes skin extremely fragile, which causes wounds and infections. Tracy Wright, Fox News, 28 Oct. 2024 According to the studies the EPA reviewed in that analysis, chloroprene is probably a mutagen—an agent that can damage DNA or trigger genetic mutations. Stephanie Pappas, Scientific American, 7 Mar. 2025 Some people have a genetic mutation that changes the way their nociceptors function and do not feel pain at all. Yenisel Cruz-Almeida, The Conversation, 27 Jan. 2025 See All Example Sentences for genetic mutation

Word History

First Known Use

1915, in the meaning defined above

Time Traveler
The first known use of genetic mutation was in 1915

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Cite this Entry

“Genetic mutation.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/genetic%20mutation. Accessed 3 Apr. 2025.

Medical Definition

genetic mutation

noun
: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes
Gaucher's disease results from one of many genetic mutations that can either slow or prevent the breakdown of certain glycolipids, which accumulate in storage vesicles and eventually kill cells.Joseph Alper
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